Pathophysiological Basis for Early Symptomatic Improvement
نویسنده
چکیده
Background. Improvement of exertional dyspnea occurs immediately after percutaneous transvenous mitral commissurotomy (PTMC), but the pathophysiological basis for this early symptomatic improvement has not been elucidated. Methods and Results. Exercise hemodynamic measurement and exercise ventilatory measurement with arterial blood gas analysis were performed in 21 patients aged 50.4+9.5 years (mean±SD) with symptomatic mitral stenosis before and a few days after PTMC. Exercise ventilatory measurement were also performed in 14 normal control subjects aged 48.9±4.9 years. After PTMC, mitral valve area increased (from 1.0±03 to 1.7±03 cm2, P<.001), mean mitral gradient (from 12.2±5.2 to 5.2±2.2
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